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Lang, Hainan
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overview Hainan Lang, M.D, Ph.D. engages in basic hearing research focused on molecular mechanisms of auditory nerve function and repair, myelin degeneration and cochlear macrophage dysfunction in presbyacusis, and auditory impairments in autism spectrum disorders. Working with collaborators within and outside MUSC, our research projects utilize a multidisciplinary approach including cell and molecular biology, auditory electrophysiology, complex mouse behavioral analyses, cochlear gene therapy, and the comparisons of the cochlear pathology between mouse models and postmortem human temporal bones.
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Academic Article Chronic reduction of endocochlear potential reduces auditory nerve activity: further confirmation of an animal model of metabolic presbyacusis.
Academic Article Sox2 up-regulation and glial cell proliferation following degeneration of spiral ganglion neurons in the adult mouse inner ear.
Academic Article Role of stromal cell-derived factor-1 expression in the injured mouse auditory nerve.
Academic Article Age-related changes of myelin basic protein in mouse and human auditory nerve.
Academic Article Nuclear factor kappaB deficiency is associated with auditory nerve degeneration and increased noise-induced hearing loss.
Concept Cochlear Nerve
Academic Article Ouabain-induced cochlear nerve degeneration: synaptic loss and plasticity in a mouse model of auditory neuropathy.
Academic Article Neural stem/progenitor cell properties of glial cells in the adult mouse auditory nerve.
Academic Article Contributions of Mouse and Human Hematopoietic Cells to Remodeling of the Adult Auditory Nerve After Neuron Loss.
Academic Article Noise-Induced Dysregulation of Quaking RNA Binding Proteins Contributes to Auditory Nerve Demyelination and Hearing Loss.
Academic Article Translational and interdisciplinary insights into presbyacusis: A multidimensional disease.
Academic Article A multi-metric approach to characterizing mouse peripheral auditory nerve function using the auditory brainstem response.
Academic Article Two distinct types of nodes of Ranvier support auditory nerve function in the mouse cochlea.
Academic Article Age-related central gain with degraded neural synchrony in the auditory brainstem of mice and humans.
Academic Article Peripheral Auditory Nerve Impairment in a Mouse Model of Syndromic Autism.
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  • Cochlear Nerve